Related Experiment Video
Updated: May 17, 2026
08:53
Label-free Single Molecule Detection Using Microtoroid Optical Resonators
Published on: December 29, 2015
A multi-parameter decoupling method with a Lamb wave sensor for improving the selectivity of label-free liquid
Lianqun Zhou1, Yihui Wu, Ming Xuan
1Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China. zhoulq@sibet.ac.cn
Sensors (Basel, Switzerland)
|November 1, 2012
Summary
This study introduces a novel liquid multi-parameter decoupling method using a single Lamb wave sensor. It accurately determines liquid density and viscosity, enhancing biosensor selectivity and unknown liquid identification.
Area of Science:
- Materials Science
- Acoustics
- Chemical Sensing
Background:
- Label-free biosensors often face challenges with selectivity.
- Accurate liquid property detection (density, sound velocity, viscosity) is crucial for various applications.
Purpose of the Study:
- To develop a single Lamb wave sensor method for multi-parameter liquid analysis.
- To decouple and determine liquid density and viscosity simultaneously.
- To improve selectivity in label-free biosensing.
Main Methods:
- Utilizing antisymmetric (A(01), A(03)) and symmetric (S(0)) Lamb wave modes.
- Employing the A(0) mode for density determination.
- Using S(0) mode amplitude shifts, correlated with density, to determine viscosity.
Main Results:
- Demonstrated the distinct roles of different Lamb wave modes in liquid property detection.
- Successfully identified liquid density using the A(0) mode.
- Calculated liquid viscosity based on density and S(0) mode amplitude shifts.
Conclusions:
- The presented method enables high-sensitivity, label-free detection of multiple liquid parameters.
- This approach offers a potential solution for selectivity issues in biosensors.
- It provides a pathway for distinguishing unknown liquids efficiently.
Related Concept Videos
01:15High-Performance Liquid Chromatography: Types of Detectors
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte properties and...
03:31Labeling DNA Probes
DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...