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Imipenem Resistance among Gram-Negative and Gram-Positive Bacteria in Hospitalized Patients

A Khorshidi1, Ar Sharif

  • 1Dept. of Microbiology, School of Medicine, Kashan University of Medical Sciences, Iran.

Iranian Journal of Public Health
|November 1, 2012
PubMed
Abstract

Insights

Imipenem resistance is a growing concern in bacterial infections. This study found high susceptibility to imipenem in E. coli, Salmonella, and Proteus, but lower rates in Pseudomonas aeruginosa.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Imipenem resistance is a significant challenge in treating Gram-positive and Gram-negative bacterial infections.
  • Hospital outbreaks underscore the urgent need to monitor antibiotic resistance patterns.

Purpose of the Study:

  • To determine the prevalence of imipenem resistance in Gram-positive and Gram-negative bacterial isolates.
  • To assess the susceptibility of common pathogens to imipenem in a specific region.

Main Methods:

  • A retrospective review of 242 hospitalized patients' culture data from 2005 in Kashan, Iran.
  • Antibiotic susceptibility testing using the Disk Diffusion method, focusing on imipenem.

Main Results:

  • Escherichia coli (96.2%), Salmonella (100%), and Proteus (100%) showed high susceptibility to imipenem.
  • Lower susceptibility rates were observed for Kelebsiella (58.4%) and Pseudomonas aeruginosa (81.8%).
  • Coagulase-negative Staphylococci and Enterococci demonstrated moderate susceptibility (79.1% and 85.7%, respectively).

Conclusions:

  • While E. coli, Salmonella, and Proteus remain susceptible to imipenem, a concerning decrease in Pseudomonas aeruginosa susceptibility was noted.
  • The findings highlight the need for regional surveillance programs to combat rising imipenem resistance.
  • Effective management of imipenem resistance is crucial due to its significant public health implications.
Keywords:
AntibioticBacteria resistanceImipenemPseudomonas

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