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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

Enteroviruses in acute myocardial infarction

T Mohamadpoor1, Ms Nabavinia, A Gholoobi

  • 1Microbiology and Virology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Iranian Journal of Public Health
|November 1, 2012
PubMed
Abstract

Insights

Enterovirus genomic RNA was detected in 2.6% of acute myocardial infarction (MI) patients. Further research is needed to confirm the role of enteroviruses in MI pathogenesis.

Area of Science:

  • Cardiology
  • Virology
  • Infectious Diseases

Background:

  • Human enteroviruses (EVs) are implicated as potential risk factors in myocardial infarction (MI) pathogenesis.
  • Evaluating the presence of enterovirus genomic RNA in peripheral blood of acute MI patients is crucial.

Purpose of the Study:

  • To assess the prevalence of enterovirus genomic RNA in the peripheral blood of patients diagnosed with acute myocardial infarction (MI).

Main Methods:

  • Reverse transcription-polymerase chain reaction (RT-PCR) was employed to detect enterovirus genomic RNA.
  • Peripheral blood samples from 115 acute MI patients were analyzed.

Main Results:

  • Enterovirus genomic RNA was detected in 3 out of 115 patient samples (2.6%) using RT-PCR.
  • The study population comprised patients with a mean age of 63.5 years, and 38.3% were female.

Conclusions:

  • A notable prevalence of enterovirus was observed in patients with myocardial infarction.
  • Additional investigations are required to establish a definitive causal relationship between enteroviruses and MI.
Keywords:
EnterovirusesMyocardial infarctionPolymerase chain reaction

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