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Mechanisms of regeneratory effects of baikal aconite diterpene alkaloids
G N Zyuz'kov1, A V Krapivin, Yu V Nesterova
1Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. zgn@pharm.tsu.ru
Abstract:
Regeneratory activities of Baikal aconite alkaloids were studied on the excision skin wound model. Manifest wound healing effects of songorine, napelline, and hypaconitine were detected. The therapeutic efficiency was based on activation of residual mesenchymal progenitor elements. The development of this phenomenon was explained by the direct effects of alkaloids on precursors and by higher production of growth factors by the skin stromal cells. Songorine exhibited the most pronounced specific activity due to more significant stimulation of progenitor cell differentiation associated with maximum activation of the secretory function of the microenvironment cells.
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