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2,8-Dihydroxyadenine uroliths in a dog
Doreen M Houston1, Andrew E Moore, Sonia Z Mendonca
1Royal Canin Canada, 100 Beiber Rd, RR 3 Guelph, ON N1H 6H9, Canada.
Journal of the American Veterinary Medical Association
|November 2, 2012
Summary
A rare case of 2,8-dihydroxyadenine (2,8-DHA) canine uroliths was diagnosed in a dog presenting with dysuria. This condition may be misdiagnosed as urate uroliths due to similar presentations.
Area of Science:
- Veterinary Urology
- Canine Nephrology
- Medical Chemistry
Background:
- Urolithiasis is a common condition in dogs, with urate uroliths being a frequent type.
- 2,8-dihydroxyadenine (2,8-DHA) uroliths are exceptionally rare in both human and canine populations.
Observation:
- A 4-year-old, 43-kg mixed-breed dog presented with a 2-day history of dysuria.
- Imaging revealed hydronephrosis, hydroureter, and uroliths in the right kidney, ureter, and urinary bladder.
Findings:
- Surgically removed uroliths were initially presumed to be urate but were confirmed as 2,8-dihydroxyadenine (2,8-DHA).
- 2,8-DHA was also detected in the dog's urine sample.
- Treatment involved allopurinol and a purine-restricted diet.
Implications:
- The rarity of 2,8-DHA uroliths in dogs highlights a potential diagnostic challenge.
- Misdiagnosis as urate uroliths is possible due to overlapping clinical signs and crystalluria characteristics.
- Accurate identification of 2,8-DHA is crucial for appropriate management and preventing recurrence.
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