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Direct catalytic anti-markovnikov hydroetherification of alkenols
David S Hamilton1, David A Nicewicz
1Department of Chemistry, University of North Carolina at Chapel Hill, 27599-3290, United States.
Abstract:
A direct intramolecular anti-Markovnikov hydroetherification reaction of alkenols is described. By employing catalytic quantities of commercially available 9-mesityl-10-methylacridinium perchlorate and 2-phenylmalononitrile as a redox-cycling source of a H-atom, we report the anti-Markovnikov hydroetherification of alkenes with complete regioselectivity. In addition, we present results demonstrating that this novel catalytic system can be applied to the anti-Markovnikov hydrolactonization of alkenoic acids.
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