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In-vitro replication studies on O(2)-methylthymidine and O(4)-methylthymidine

Nisana Andersen1, Jianshuang Wang, Pengcheng Wang

  • 1Department of Chemistry, University of California, Riverside, CA 92521-0403, USA.

Chemical Research in Toxicology
|November 2, 2012
PubMed
Summary

Methylated thymidine adducts (O(2)-MdT and O(4)-MdT) block DNA synthesis and cause mutations. DNA polymerases show varied responses, with some misincorporating nucleotides opposite these lesions, potentially leading to genetic alterations.

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