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Risk factors associated with brachial-ankle pulse wave velocity among peritoneal dialysis patients in Macao

Ding-Wei Kuang1, Chiu-Leong Li, Un-I Kuok

  • 1Divion of Nephrology, Centro Hospitalar Conde de São Januário, Macao SAR, PR China.

BMC Nephrology
|November 2, 2012
PubMed

Insights

Arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), is linked to age, low serum albumin, high CRP, and reduced renal function in peritoneal dialysis patients. These factors are key predictors of cardiovascular risk in this population.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Biology

Background:

  • Cardiovascular disease (CVD) is the primary cause of death in peritoneal dialysis (PD) patients in Macao.
  • Increased arterial stiffness, quantified by pulse wave velocity (PWV), is an independent predictor of CVD mortality in end-stage renal disease (ESRD).

Purpose of the Study:

  • To investigate the relationship between arterial stiffness and its associated risk factors in chronic PD patients in Macao.
  • To identify predictors of arterial stiffness in this patient cohort.

Main Methods:

  • A cross-sectional study included 96 chronic PD patients (48 males/48 females).
  • Arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV).
  • Clinical characteristics and biochemical parameters were collected, and patients were stratified by mean baPWV.

Main Results:

  • Patients with high baPWV were older, more likely female, and had a history of CVD.
  • High baPWV group exhibited lower serum albumin, pre-albumin, and residual renal creatinine clearance (CCr), but higher serum ferritin.
  • baPWV positively correlated with age, Charlson comorbidity index, and serum ferritin; negatively with albumin, pre-albumin, and CCr. Age-adjusted analysis showed correlation with CRP.

Conclusions:

  • Arterial stiffness, assessed by baPWV, is independently associated with age, serum albumin, C-reactive protein (CRP), and residual renal CCr in PD patients.
  • These findings highlight modifiable and non-modifiable factors contributing to arterial stiffness in PD patients.
Abstract

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