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Chitosan: evaluation of a new hemostatic agent
G M Kind1, S D Bines, E D Staren
1Department of General Surgery, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
Current Surgery
|January 1, 1990
Summary
Topical chitosan did not improve bleeding control in liver injuries compared to pressure alone. Thrombin was more effective, and chitosan may increase liver inflammation.
Area of Science:
- Biomedical Engineering
- Surgical Hemostasis
- Wound Healing
Background:
- Topical hemostatic agents are crucial for managing surgical bleeding.
- Chitosan, a biopolymer, has shown potential in wound healing and hemostasis.
- Its efficacy in controlling liver bleeding requires further investigation.
Purpose of the Study:
- To evaluate the effectiveness of topical chitosan in controlling bleeding from liver lacerations.
- To compare chitosan's hemostatic effect with pressure alone and thrombin.
- To assess the impact of chitosan on liver tissue healing and inflammation.
Main Methods:
- A liver laceration model was created in normal and heparinized rats.
- Topical chitosan was applied and compared to pressure alone and thrombin.
- Bleeding control was quantified, and liver histology was examined.
Main Results:
- Topical chitosan did not significantly improve bleeding control compared to pressure alone in both rat groups.
- Both chitosan and pressure alone were significantly less effective than thrombin in controlling bleeding.
- Histological analysis suggested a potential increase in inflammatory response in the liver following chitosan application.
Conclusions:
- Topical chitosan is not effective in controlling bleeding from liver lacerations.
- Thrombin demonstrates superior hemostatic efficacy compared to chitosan and pressure alone.
- Chitosan may induce an adverse inflammatory response in healing liver tissue.