Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Mismatch Repair01:36

Mismatch Repair

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Update on the comparative <i>in vitro</i> activity of cefiderocol and four β-lactam-β-lactamase-inhibitor combinations against clinically important Gram-negative pathogens.

JAC-antimicrobial resistance·2026
Same author

Concerning emergence of a new vancomycin-resistant Enterococcus faecium strain ST1299/CT1903/vanA at a tertiary university centre in South Germany.

The Journal of hospital infection·2023
Same author

Bacterial production of recombinant contraceptive vaccine antigen from CatSper displayed on a human papilloma virus-like particle.

Vaccine·2023
Same author

Epidemiology and outcomes of vancomycin-resistant enterococcus infections: a systematic review and meta-analysis.

The Journal of hospital infection·2023
Same author

[Toxic shock syndrome due to <i>Staphylococcus aureus</i> in a small child, a (clinical or laboratory chemical) visual diagnosis?]

Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde·2020
Same author

Temocillin susceptibility in Enterobacterales with an ESBL/AmpC phenotype.

International journal of antimicrobial agents·2020

Related Experiment Video

Updated: May 17, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

[Current data and trends on methicillin-resistant Staphylococcus aureus (MRSA)].

F Layer1, C Cuny, B Strommenger

  • 1Nationales Referenzzentrum für Staphylokokken und Enterokokken, Robert Koch-Institut, Burgstrasse 37, Wernigerode, Germany. layerf@rki.de

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
|November 2, 2012
PubMed
Summary

Methicillin-resistant Staphylococcus aureus (MRSA) hospital infections are a global concern. Molecular surveillance tracks MRSA clone dynamics, antibiotic resistance, and spread, aiding in prevention strategies.

More Related Videos

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Related Experiment Videos

Last Updated: May 17, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Epidemiology

Background:

  • Nosocomial infections caused by methicillin-resistant Staphylococcus aureus (MRSA) represent a significant global healthcare challenge.
  • Effective surveillance is crucial for understanding and controlling the spread of MRSA within hospital environments.

Purpose of the Study:

  • To analyze recent data on antibiotic resistance and epidemic MRSA strains in nosocomial settings.
  • To assess the impact of community-acquired MRSA and MRSA originating from zoonotic reservoirs.
  • To highlight the ongoing challenge of identifying MRSA clones and the need for molecular surveillance.

Main Methods:

  • Molecular typing of a representative sample of MRSA isolates from German hospitals.
  • Analysis of recent epidemiological data on MRSA trends.
  • Assessment of antibiotic resistance patterns.

Main Results:

  • Long-term trends in MRSA emergence and spread dynamics were monitored.
  • Data on antibiotic resistance and epidemic MRSA in nosocomial settings were presented.
  • The influence of community-acquired and zoonotic MRSA was considered.

Conclusions:

  • Identifying common and emerging MRSA clones remains a challenge.
  • Molecular surveillance is essential for tracking MRSA epidemiology.
  • Effective prevention of MRSA spread necessitates ongoing molecular surveillance.