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How should we investigate CUO (C-Reactive Protein elevation of unknown origin)? A case-based discussion of infective
Joanna C Ford1, D Gwyn Seymour, Donald M Newnham
1Department of Geriatric Medicine, Woodend Hospital, Aberdeen, UK. Joanna.Lindsay@nhs.net
Insights
Diagnosing chronic infections can be challenging, especially in older adults who may present atypically. Serum C-reactive protein (CRP) can help identify infections and monitor their resolution in this population.
Area of Science:
- Geriatric Medicine
- Infectious Diseases
- Clinical Chemistry
Background:
- Chronic infections, including infective endocarditis, present diagnostic challenges across all age groups.
- Atypical presentations of chronic infections are more common in the elderly population.
Abstract:
Infective endocarditis and other chronic infections may cause diagnostic difficulties, regardless of age. The likelihood of an atypical presentation of chronic infection probably increases with age. Serum CRP may be a useful guide to the presence of underlying infection and its resolution in older people. The term CUO (CRP elevation of unknown origin) may have a place in triggering further investigation for the presence of infection or other pathology.
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