Related Experiment Videos
[Secondary effects caused by feed medication in swine]
1Klinik für kleine Klauentiere und forensische Medizin und Ambulatorischen Klinik der Tierärztlichen Hochschule Hannover.
DTW. Deutsche Tierarztliche Wochenschrift
|January 1, 1990
Summary
Certain drug combinations can induce vitamin K deficiency in weanling pigs by disrupting intestinal flora, leading to blood coagulation disorders and hemorrhages. Sulfadimidine was frequently associated with these adverse effects.
Area of Science:
- Veterinary Medicine
- Animal Nutrition
- Biochemistry
Context:
- Medical feed additives can inadvertently cause vitamin K deficiency in weanling pigs.
- Intestinal flora disruption is a key factor in developing vitamin K deficiency.
- Vitamin K deficiency impacts blood coagulation, leading to hemorrhagic symptoms.
Purpose:
- To investigate the effects of various drug combinations on blood coagulation in vitamin K-deficient weanling pigs.
- To determine the role of specific drugs (sulfadimidine, tylosin, furazolidone, arsanilic acid) in inducing coagulation disorders.
- To assess the influence of prior drug exposure and housing conditions on vitamin K deficiency development.
Summary:
- A combination of sulfadimidine, tylosin, furazolidone, and arsanilic acid induced clinical signs of vitamin K deficiency and hemorrhage in weanling pigs.
- While single drug or different combinations showed minimal effects, sulfadimidine/arsanilic acid significantly altered coagulation factors.
- Pre-treatment in suckling pigs did not prevent coagulation disorders post-weaning, suggesting individual intestinal flora resistance and bacterial count are critical.
Impact:
- Findings indicate that specific drug combinations can compromise swine health by inducing vitamin K deficiency.
- The study underscores the importance of considering drug-induced gut dysbiosis in swine nutrition and health management.
- Results suggest individual variability in intestinal flora plays a role in susceptibility to vitamin K deficiency.