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Related Experiment Video

Updated: May 17, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Does a decrease of NK cells in the appendix increase the risk of developing colon cancer?

Cai Yuan-Kun1, Ye Tao

  • 1Department of General Surgery, The Fifth People's Hospital of Shanghai Affiliated to Fudan University, Shanghai, China. yuankun@medmail.com.cn

Hepato-Gastroenterology
|November 2, 2012
PubMed
Summary
This summary is machine-generated.

A decrease in natural killer (NK) cells within the appendix correlates with an increased risk of right colon cancer. This finding offers a new immune indicator for colon cancer risk assessment.

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A Flow Cytometry-Based Cytotoxicity Assay for the Assessment of Human NK Cell Activity
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Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

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A Flow Cytometry-Based Cytotoxicity Assay for the Assessment of Human NK Cell Activity
06:08

A Flow Cytometry-Based Cytotoxicity Assay for the Assessment of Human NK Cell Activity

Published on: August 9, 2017

Area of Science:

  • Immunology
  • Oncology
  • Gastroenterology

Background:

  • The relationship between the appendix and colon cancer remains controversial.
  • Existing epidemiological data lacks immune indicator insights.
  • The role of appendix immunity in right colon cancer is under-explored.

Purpose of the Study:

  • To investigate the association between appendix immunity and right colon cancer.
  • To determine if natural killer (NK) cell presence in the appendix is linked to colon cancer incidence.

Main Methods:

  • Utilized immunohistochemistry to detect NK cells in appendix tissues.
  • Quantified NK cell numbers in appendix samples from different patient groups.

Main Results:

  • Appendix tissues from patients with inflammation showed the highest NK cell counts (37.2±1.1).
  • Patients with right colon cancer and normal appendix tissues exhibited lower NK cell counts (30.9±1.7).

Conclusions:

  • A reduction in NK cells in the appendix is associated with a higher incidence of right colon cancer.
  • NK cell levels in the appendix may serve as a potential biomarker for colon cancer risk.