Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ethics in Research

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

Blind Procedures

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...

Nurses' Legal Responsibilities I

Nurses' Legal Responsibilities I

In healthcare, informed consent is a crucial process that involves thoroughly communicating medical treatment options to patients, including benefits, risks, potential side effects, and alternatives. This process enables patients to make well-informed decisions about their care, ensuring they understand the implications of their choices before consenting to or refusing treatment.
The legal responsibilities of a nurse regarding informed consent include the following:

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same journal

Report of the International Bioethics Committee (IBC) on Updating Its Reflection on the Human Genome and Human Rights. FINAL RECOMMENDATIONS.

Revista de derecho y genoma humano = Law and the human genome review·2016

Same journal

[Not Available].

Revista de derecho y genoma humano = Law and the human genome review·2016

Same journal

[Not Available].

Revista de derecho y genoma humano = Law and the human genome review·2016

Same journal

[Not Available].

Revista de derecho y genoma humano = Law and the human genome review·2016

Same journal

[Not Available].

Revista de derecho y genoma humano = Law and the human genome review·2016

Same journal

[Not Available].

Revista de derecho y genoma humano = Law and the human genome review·2016

Search research articles

Related Experiment Video

Updated: May 17, 2026

Working with Human Tissues for Translational Cancer Research

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

[Information sheet and informed consent in biomedical research with samples].

Cristina Gil Membrado¹

¹Universidad de las Islas Baleares, Islas Baleares, España.

Revista De Derecho Y Genoma Humano = Law and the Human Genome Review

|November 3, 2012

Summary

This study evaluates clinical trial participant information sheets for pharmacogenetic and pharmacogenomic studies. It provides a guide to ensure compliance with regulations on data protection and biological sample handling.

More Related Videos

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications

Published on: September 2, 2025

Related Experiment Videos

Last Updated: May 17, 2026

Working with Human Tissues for Translational Cancer Research

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications

Published on: September 2, 2025

Area of Science:

Pharmacogenetics and Pharmacogenomics
Clinical Trial Methodology
Bioethics and Regulatory Science

Context:

Clinical trials increasingly incorporate pharmacogenetic and pharmacogenomic studies.
Ensuring adequate participant understanding is crucial for informed consent.
Regulatory frameworks govern clinical trials, biological samples, and personal data protection.

Purpose:

To practically assess the content of participant information sheets for clinical trials involving pharmacogenetic/pharmacogenomic research.
To clarify the scope of informed consent within these specific trial types.
To develop a tool for evaluating the regulatory compliance of information sheets.

Summary:

The paper analyzes the essential components of participant information sheets for pharmacogenetic and pharmacogenomic clinical trials.
It examines the breadth and clarity of informed consent information provided to participants.
A question-based guide is presented to help assess the suitability of these sheets against current regulations.

Impact:

Aims to improve the quality and regulatory adherence of participant information materials.
Facilitates better informed consent processes in pharmacogenetic and pharmacogenomic research.
Supports researchers and ethics committees in developing compliant and participant-centric trial documentation.