Transient myocardial ischaemia: a multivariate analysis on clinical, angiographic and ergometric variables
C Pandullo1, S Scardi, G Ceschia
1Centro Di Cardiologia, Ospedale Maggiore, Trieste, Italy.
Insights
Ambulatory ECG monitoring can identify transient myocardial ischemia in patients with ischemic heart disease. Exercise test duration and peak heart rate predict its occurrence, aiding patient selection for further ECG monitoring.
Area of Science:
- Cardiology
- Diagnostic Medicine
Background:
- Ambulatory ECG monitoring aids in identifying transient myocardial ischemia.
- The clinical significance of transient myocardial ischemia is under ongoing investigation.
Purpose of the Study:
- To evaluate the prevalence of transient myocardial ischemia during 24-hour dynamic ECG.
- To identify clinical, angiographic, and ergometric predictors of transient myocardial ischemia.
Main Methods:
- Studied 94 patients with ischemic heart disease and positive exercise tests.
- Utilized 24-hour dynamic electrocardiogram (ECG) monitoring.
- Analyzed clinical, angiographic, and ergometric variables.
Main Results:
- Recorded 281 episodes of transient myocardial ischemia in 69 patients (73.4%).
- Diabetes, previous myocardial infarction, and multivessel disease showed non-significant trends towards higher prevalence.
- Exercise test duration to ischemic threshold and peak heart rate were significant predictors (P=0.019 and P=0.012).
- Patients with ischemia had lower ischemic thresholds and peak heart rates.
Conclusions:
- Exercise testing can help select patients for dynamic ECG examination.
- Predictors of transient myocardial ischemia include exercise test duration and peak heart rate.
Abstract:
The availability of ambulatory ECG monitoring allows identification of transient myocardial ischaemia, the clinical relevance of which is currently being investigated. Ninety-four consecutive patients with ischaemic heart disease and a positive exercise test (greater than or equal to 1 mm ST-segment depression) were studied to evaluate the prevalence of transient myocardial ischaemia (either painless or painful) during 24-h dynamic electrocardiogram (ECG) and the clinical, angiographic and ergometric variables predicting its appearance. Two-hundred-and-eighty-one episodes of transient electocardiographic myocardial ischaemia were recorded in 69 patients (73.4% of all patients). Transient myocardial ischaemia was more frequent, although not significantly so, in patients with diabetes, with previous myocardial infarction, or with multivessel disease. When tested by multivariate analysis, neither the clinical variables nor the severity of coronary artery disease allowed prediction of the occurrence of transient myocardial ischaemia during dynamic ECG. The duration of exercise testing up to the ischaemic threshold (ST-segment depression = 1 mm) and the peak heart rate during exercise were more accurate predictors of transient myocardial ischaemia (P = 0.019 and 0.012 respectively). Patients with transient myocardial ischaemia had a lower ischaemic threshold (355 +/- 175 vs 498 +/- 150 s, mean +/- SD, P = 0.001) despite a lower peak heart rate (129 +/- 18 vs 137 +/- 12 beats min-1, P = 0.047) than patients without transient myocardial ischaemia. In conclusion, exercise testing may help select patients for examination by dynamic ECG.(ABSTRACT TRUNCATED AT 250 WORDS)
Related Concept Videos
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Acute Coronary Syndrome III: Diagnostic Studies
Angina III: Clinical Manifestations and Assessment
Transient Ischemic Attack l: Introduction


