Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...

Parkinson Disease ll: Pathophysiology

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

Parkinson Disease l: Introduction

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Unveiling Intrinsic Triplet Superconductivity in Noncentrosymmetric NbRe through Inverse Spin-Valve Effects.

Physical review letters·2025

Same author

Use of levetiracetam for the successful treatment of suspected myoclonic seizures: five dogs (2016-2022).

The Journal of small animal practice·2024

Same author

Bayesian rank-based hypothesis testing for the rank sum test, the signed rank test, and Spearman's <i>ρ</i>.

Journal of applied statistics·2022

Same author

Absence of high-risk human papilloma virus in p16 positive inverted sinonasal papilloma.

European annals of otorhinolaryngology, head and neck diseases·2019

Same author

First Report of Xanthomonas arboricola pv. pruni in Ornamental Prunus laurocerasus in the Netherlands.

Plant disease·2019

Same author

Acoustic formation of multicellular tumor spheroids enabling on-chip functional and structural imaging.

Lab on a chip·2018

Search research articles

Related Experiment Video

Updated: May 17, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Deep brain stimulation - effects on swallowing function in Parkinson's disease.

L Kulneff¹, S Sundstedt, K Olofsson

¹Division of Speech and Language Pathology, Department of Clinical Sciences, Umeå University, Sweden.

Acta Neurologica Scandinavica

|November 3, 2012

Summary

Deep brain stimulation of the subthalamic nucleus (STN DBS) did not significantly alter swallowing function in Parkinson's disease (PD) patients, though self-assessments indicated subjective improvement. The risk of aspiration was not increased by STN DBS.

More Related Videos

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

Related Experiment Videos

Last Updated: May 17, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

Area of Science:

Neurology
Neurosurgery
Swallowing Disorders

Background:

Parkinson's disease (PD) affects motor control, including swallowing.
Subthalamic nucleus deep brain stimulation (STN DBS) is effective for motor symptoms in PD.
The impact of STN DBS on swallowing function remains understudied.

Purpose of the Study:

To assess the effect of STN DBS on pharyngeal swallowing function in PD patients.
To compare subjective self-estimation with objective fiberoptic endoscopic evaluation of swallowing.

Main Methods:

Eleven PD patients underwent evaluation preoperatively and 6, 12 months post-STN DBS.
Swallowing was assessed using visual analogue scales (self-estimation) and fiberoptic endoscopy.
Endoscopic evaluation included Penetration-Aspiration Scale, Secretion Severity Scale, and pharyngeal residue/clearance assessments.

Main Results:

Patient self-assessments showed subjective improvement in swallowing post-STN DBS.
Objective swallowing protocol data revealed no significant effect of STN DBS on pharyngeal function.
The prevalence of aspiration events did not change significantly after surgery.

Conclusions:

STN DBS does not negatively impact swallowing function in PD patients.
The risk of aspiration is not increased following STN DBS.
Subjective improvements in swallowing are reported by patients receiving STN DBS.