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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

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Related Experiment Video

Updated: May 17, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Mast cells and inflammation.

Laurent Frenzel1, Olivier Hermine

  • 1Service d'Hématologie Adulte, Centre de référence des mastocytoses, CNRS UMR 8147, Institut Imagine, Hôpital Necker-Enfants-Malades, 75015 Paris, France. frenzel_laurent@hotmail.com

Joint Bone Spine
|November 3, 2012
PubMed
Summary
This summary is machine-generated.

Mast cells are key players in inflammation and immune responses. Targeting mast cell receptors with tyrosine-kinase inhibitors shows promise for treating inflammatory diseases like rheumatoid arthritis and multiple sclerosis.

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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

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Last Updated: May 17, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Area of Science:

  • Immunology
  • Pharmacology

Background:

  • Mast cells play a significant role in inflammatory responses.
  • They are involved in maintaining homeostasis and allergic reactions.
  • Mast cells are crucial in both innate and adaptive immunity.

Purpose of the Study:

  • To highlight the role of mast cells in chronic inflammatory diseases.
  • To identify mast cells as a therapeutic target.
  • To discuss the efficacy of tyrosine-kinase inhibitors.

Main Methods:

  • Review of existing literature on mast cell function.
  • Analysis of therapeutic strategies targeting mast cells.
  • Evaluation of tyrosine-kinase inhibitors in disease models.

Main Results:

  • Mast cells are implicated in rheumatoid arthritis and multiple sclerosis.
  • Tyrosine-kinase inhibitors targeting c-Kit receptor are effective.
  • These inhibitors show efficacy in rheumatoid arthritis, asthma, and multiple sclerosis.

Conclusions:

  • Mast cells are valuable therapeutic targets for chronic inflammatory diseases.
  • Tyrosine-kinase inhibitors offer a promising treatment avenue.
  • Combination therapy with tyrosine-kinase inhibitors may enhance treatment outcomes.