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Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies
14:48

Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies

Published on: December 26, 2012

[Alveolar epithelial cell injury as an etiopathogenic factor in pulmonary fibrosis]

Anna Serrano-Mollar1

  • 1Departamento de Patología Experimental, Institut d'Investigacions Biomèdiques de Barcelona, España. anna.serranomollar@iibb.csic.es

Archivos De Bronconeumologia
|November 3, 2012
PubMed

Idiopathic pulmonary fibrosis (IPF) is characterized by a progressive accumulation of extracellular matrix and an imbalance between profibrotic and antifibrotic mediators. In the last few years, understanding of the mechanisms of the biology of IPF has increased. One of the most significant discoveries is the finding that alveolar epithelial cell injury plays an important role in the pathogenesis of this disease. In this review, we describe some of the mechanisms involved in alveolar cell injury and their contribution to the development of IPF.

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