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High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

High-throughput Identification of Synergistic Drug Combinations by the Overlap² Method

Published on: May 21, 2018

Expanding medicinal chemistry space.

Andy Barker¹, Jason G Kettle, Thorsten Nowak

¹AstraZeneca R&D, Oncology iMed, Alderley Park, Macclesfield SK10 4TG, UK.

Drug Discovery Today

|November 3, 2012

Summary

New technologies are emerging to target previously undruggable proteins, expanding therapeutic options. This research reviews novel approaches for generating drug leads against challenging biological targets.

Area of Science:

Drug discovery and development
Medicinal chemistry
Biotechnology

Background:

Most clinically useful drugs target a limited set of proteins within accessible chemical space.
Numerous high-value biological targets remain 'intractable' to traditional small molecule drugs.
Accessing these targets could significantly advance therapeutic options and benefit the pharmaceutical industry.

Purpose of the Study:

To review emerging technologies and approaches for drug discovery.
To explore novel lead generation capabilities for targeting intractable biological targets.
To identify strategies for accessing new classes of drug targets.

Main Methods:

Literature review of recent advancements in drug discovery technologies.

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Universal Molecular Retention with 11-Fold Expansion Microscopy

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High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

High-throughput Identification of Synergistic Drug Combinations by the Overlap² Method

Published on: May 21, 2018

Universal Molecular Retention with 11-Fold Expansion Microscopy

Universal Molecular Retention with 11-Fold Expansion Microscopy

Published on: October 6, 2023

Analysis of novel approaches for lead generation against challenging targets.

Evaluation of the potential of new technologies to address previously undruggable targets.

Main Results:

Emerging technologies show promise in overcoming limitations of traditional drug discovery.
New approaches are being developed to generate leads for previously inaccessible target classes.
Success in accessing intractable targets remains limited but is improving with new methodologies.

Conclusions:

Novel technologies are crucial for expanding the scope of treatable diseases.
Continued innovation in drug discovery is needed to tackle a new generation of biological targets.
The development of new lead generation capabilities will be key to future pharmaceutical advancements.