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Related Experiment Video

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A Low Cost Setup for Behavioral Audiometry in Rodents
09:23

A Low Cost Setup for Behavioral Audiometry in Rodents

Published on: October 16, 2012

A low cost setup for behavioral audiometry in rodents.

Konstantin Tziridis1, Sönke Ahlf, Holger Schulze

  • 1Experimental Otolaryngology, University of Erlangen-Nuremberg. Konstantin.Tziridis@uk-erlangen.de

Journal of Visualized Experiments : Jove
|November 3, 2012
PubMed
Summary

Assessing animal hearing perception requires behavioral methods. Pre-pulse inhibition of the acoustic startle response (ASR) offers a learning-free approach to determine hearing thresholds and impairments in animal models.

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Area of Science:

  • Auditory Neuroscience
  • Animal Behavior
  • Sensory Physiology

Background:

  • Accurate hearing parameter assessment is vital in auditory animal research.
  • Physiological measures like brainstem audiometry (BERA) offer indirect hearing insights.
  • Behavioral methods are needed for perceptual hearing assessment but often involve learning paradigms that can alter perception.

Purpose of the Study:

  • To introduce and validate a behavioral method for assessing auditory perception in naïve animals.
  • To utilize the acoustic startle response (ASR) and its modulation by pre-stimuli for hearing assessment.
  • To establish a learning-free paradigm for determining behavioral audiograms and detecting hearing impairments.

Main Methods:

  • Employing the acoustic startle response (ASR) in naïve Mongolian gerbils (Meriones unguiculatus).
  • Utilizing pre-pulse inhibition (PPI) of the ASR, where the degree of inhibition correlates with the perceptibility of the pre-pulse.
  • Establishing a behavioral audiogram based on the PPI magnitude across different sound frequencies and intensities.

Main Results:

  • Pre-pulse inhibition (PPI) of the acoustic startle response (ASR) demonstrates a graded dependency on the perceptibility of the pre-stimulus.
  • The PPI of ASR effectively differentiates between sounds above and near the hearing threshold.
  • The method successfully generated behavioral audiograms in a rodent model without prior training.

Conclusions:

  • Pre-pulse inhibition (PPI) of the acoustic startle response (ASR) is a robust, learning-free method for assessing auditory perception in animal models.
  • This technique is suitable for determining behavioral audiograms, identifying hearing impairments, and potentially detecting subjective tinnitus.
  • The Mongolian gerbil serves as an effective model for startle response research within the human hearing range.