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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

951
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
951
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.5K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.5K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

611
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
611
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

1.1K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
1.1K
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

523
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
523

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Related Experiment Video

Updated: Jan 31, 2026

Separation and Fractionation of Cell Wall and Cell Membrane Proteins from Mycobacterium tuberculosis for Downstream Protein Analysis
06:14

Separation and Fractionation of Cell Wall and Cell Membrane Proteins from Mycobacterium tuberculosis for Downstream Protein Analysis

Published on: September 26, 2025

639

Ofloxacin in miliary tuberculosis.

J Alegre1, T Fernández de Sevilla, V Falcó

  • 1Department of Internal Medicine, Hospital Valle Hebrón, Universidad Autonoma, Barcelona, Spain.

The European Respiratory Journal
|February 1, 1990
PubMed
Summary

Severe miliary tuberculosis can cause liver and respiratory failure. Ofloxacin and cycloserine treatment for nine months was effective, despite some toxicities.

Area of Science:

  • Internal Medicine
  • Infectious Diseases
  • Pulmonology

Background:

  • Miliary tuberculosis is a severe disseminated form of Mycobacterium tuberculosis infection.
  • Liver failure and respiratory insufficiency are critical complications of advanced tuberculosis.

Observation:

  • A 27-year-old patient presented with severe miliary tuberculosis, complicated by liver failure and respiratory insufficiency.
  • The patient experienced hepatic, ocular, and vestibular toxicities during treatment.

Findings:

  • A nine-month treatment regimen of ofloxacin and cycloserine was administered.
  • This regimen demonstrated effectiveness in managing the severe miliary tuberculosis.

Implications:

  • This case highlights the potential for severe organ damage in miliary tuberculosis.

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  • The study underscores the therapeutic utility of ofloxacin and cycloserine in prolonged treatment regimens.
  • Monitoring for and managing treatment-related toxicities is crucial in severe tuberculosis cases.