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Related Experiment Video

Updated: May 17, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Postoperative kidney injury does not decrease survival after liver transplantation.

Olival Cirilo Lucena da Fonseca-Neto¹, Luiz Eduardo Correia Miranda, Thales Paulo Batista

¹Division of Abdominal Surgery, Department of Surgery, UPE, Pernambuco, Brazil. olivalneto@globo.com

Acta Cirurgica Brasileira

|November 3, 2012

Summary

Postoperative acute kidney injury (AKI) did not independently impact long-term survival in liver transplant patients. However, early mortality was higher in patients who developed AKI, highlighting the need for careful monitoring.

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Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

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Area of Science:

Nephrology
Hepatology
Transplantation Surgery

Background:

Orthotopic liver transplantation (OLT) is a life-saving procedure for end-stage liver disease.
Acute kidney injury (AKI) is a common complication following OLT, potentially affecting patient outcomes.
The impact of AKI on long-term survival after OLT without venovenous bypass (VVB) requires further investigation.

Purpose of the Study:

To determine the effect of AKI on long-term patient survival after OLT performed without VVB.
To analyze the association between AKI and survival outcomes in liver transplant recipients.

Main Methods:

A retrospective cohort study included 153 patients undergoing OLT without VVB.
Kaplan-Meier survival estimates and log-rank tests were used to assess survival.
Multivariate analyses controlled for confounding variables.

Main Results:

Over a median follow-up of 4.5 years, 58.8% of patients survived.
Early postoperative mortality was higher in patients who developed AKI (20% vs. 5.4%).
Long-term 5-year survival did not significantly differ between patients with and without AKI (65.3% vs. 51.4%). AKI was not an independent predictor of long-term survival.

Conclusions:

Postoperative AKI did not independently reduce long-term survival after OLT without VVB.
Intraoperative red blood cell transfusion was significantly associated with long-term survival.
These findings, from northeast Brazil, suggest AKI's role in early mortality but not long-term survival in this specific OLT context.