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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...

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Related Experiment Video

Updated: May 17, 2026

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
08:26

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

Does the adult stroma contain stem cells?

Richard Schäfer1

  • 1Department of Neurosurgery, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA, 94305-5487, USA, rsmd@stanford.edu.

Advances in Biochemical Engineering/Biotechnology
|November 3, 2012
PubMed
Summary

Adult mesenchymal stromal cells (MSCs) may have distinct subpopulations with unique stem cell properties. Understanding these MSC subpopulations offers insights for basic and translational research.

Area of Science:

  • Stem cell biology
  • Cellular and molecular medicine

Background:

  • Adult mesenchymal stromal cells (MSCs) are generally considered to have uniform phenotypical and functional properties.
  • Emerging evidence suggests heterogeneity within MSC populations, indicating distinct subpopulations.

Purpose of the Study:

  • To explore mesenchymal stromal cell (MSC) subpopulations.
  • To compare MSC subpopulations with pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
  • To provide an ontogenetic perspective on MSCs for research applications.

Main Methods:

  • Literature review and synthesis focusing on MSC heterogeneity.
  • Comparative analysis of MSC subpopulations and pluripotent stem cells (PSCs).

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Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles
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Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles

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Stromal Cell Isolation From Hematopoietic Organs

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Related Experiment Videos

Last Updated: May 17, 2026

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
08:26

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles
07:00

Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles

Published on: April 6, 2013

Stromal Cell Isolation From Hematopoietic Organs
05:27

Stromal Cell Isolation From Hematopoietic Organs

Published on: January 26, 2024

Main Results:

  • Mesenchymal stromal cells (MSCs) likely consist of subpopulations with varying characteristics.
  • These subpopulations may exhibit distinct stem cell properties.
  • Comparison with pluripotent stem cells (PSCs) highlights potential ontogenetic relationships.

Conclusions:

  • Recognizing MSC subpopulations is crucial for advancing stem cell research.
  • This understanding can bridge basic science discoveries with clinical applications.
  • Further investigation into MSC heterogeneity is warranted.