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Related Experiment Videos

C-reactive protein during normal pregnancy.

F R Nielsen1, K M Bek, P E Rasmussen

  • 1Department of Obstetrics and Gynecology, Sct Maria Hospital, Vejle, Denmark.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|April 1, 1990
PubMed
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Serum C-reactive protein (CRP) levels during pregnancy appear normal and do not change with gestational age. A rising CRP level is a better infection indicator, and CRP may help diagnose newborn infections as it doesn't cross the placenta.

Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Medicine
  • Clinical Chemistry

Background:

  • Serum C-reactive protein (CRP) is a marker of inflammation.
  • Understanding normal CRP levels in pregnancy is crucial for accurate diagnosis.

Purpose of the Study:

  • To establish normal serum C-reactive protein (CRP) concentrations in low-risk pregnant women.
  • To assess the utility of CRP in diagnosing neonatal infections.

Main Methods:

  • Prospective longitudinal study of 60 low-risk pregnant women.
  • Serum CRP levels measured during pregnancy and in umbilical-cord blood post-delivery.

Main Results:

  • Serum CRP concentrations were independent of pregnancy and gestational age.

Related Experiment Videos

  • The 95th percentile for serum CRP was estimated at 20 mg/l, defining the upper limit of normal.
  • A rising CRP level was found to be more predictive of infection than a single high value.

    • Conclusions:

    • Normal serum CRP levels in low-risk pregnancy are established.
    • CRP does not cross the placental barrier, suggesting its potential as a diagnostic tool for neonatal infections.