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Updated: May 17, 2026
08:35
Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
Published on: June 24, 2021
HEXEvent: a database of Human EXon splicing Events
1Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697-4025, USA.
Nucleic Acids Research
|November 3, 2012
Summary
HEXEvent is a new database for compiling human exon data, focusing on alternative splicing events. It allows users to customize queries and download datasets for further analysis of exon splicing.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- Alternative splicing is a key mechanism regulating gene expression in humans.
- Understanding exon splicing patterns is crucial for deciphering cellular function and disease.
- Existing databases may lack comprehensive features for analyzing genome-wide splicing events.
Purpose of the Study:
- To introduce HEXEvent, a novel database for exploring human internal exon splicing.
- To provide customizable query options for analyzing alternative splicing events.
- To facilitate the extraction and download of exon splicing datasets for research.
Main Methods:
- Development of the HEXEvent database (http://hexevent.mmg.uci.edu).
- Implementation of user-defined queries based on splicing event type and frequency.
- Inclusion of EST counts to quantify splicing event frequency.
- User-definable parameters for constitutive and alternatively spliced exons.
Main Results:
- HEXEvent enables the compilation of genome-wide exon data sets for human internal exons.
- Users can specify criteria for exon inclusion/exclusion levels.
- The database provides downloadable datasets for individual, multiple, or genome-wide exons.
- EST counts offer quantitative insights into splicing event frequencies.
Conclusions:
- HEXEvent offers a unique and flexible platform for analyzing human alternative splicing.
- The database empowers researchers to extract and analyze custom splicing datasets.
- HEXEvent enhances the study of exon splicing patterns and their functional implications.
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There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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