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Methemoglobinemia associated with metoclopramide therapy in a neonate

Kristine G Palmer1, Laura P James

  • 1University of Arkansas for Medical Sciences, Little Rock, Arkansas.

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
|November 3, 2012
PubMed

Insights

Metoclopramide is increasingly used for pediatric gastroesophageal reflux. A neonate developed methemoglobinemia from a slightly high dose, highlighting a serious risk for infants.

Area of Science:

  • Pediatric Gastroenterology
  • Neonatal Pharmacology
  • Clinical Toxicology

Background:

  • Cisapride removal led to increased metoclopramide use for pediatric gastroesophageal reflux.
  • Metoclopramide is a common alternative for treating reflux in infants.

Observation:

  • A case report details a neonate treated with metoclopramide.
  • The infant received doses slightly exceeding the recommended pediatric dosage.

Findings:

  • The neonate developed methemoglobinemia, a serious adverse reaction.
  • This occurred despite a modest dose increase above age-appropriate recommendations.

Implications:

  • Healthcare providers must be vigilant for methemoglobinemia in infants receiving metoclopramide.
  • Awareness of this risk is crucial for safe pediatric prescribing practices.
  • Careful dosing and monitoring are essential to prevent adverse events in neonates.

Keywords:
methemoglobinemiametoclopramideneonate

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