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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
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Initiation and regulation of complement during hemolytic transfusion reactions

Sean R Stowell1, Anne M Winkler, Cheryl L Maier

  • 1Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

Clinical & Developmental Immunology
|November 3, 2012
PubMed

Hemolytic transfusion reactions represent one of the most common causes of transfusion-related mortality. Although many factors influence hemolytic transfusion reactions, complement activation represents one of the most common features associated with fatality. In this paper we will focus on the role of complement in initiating and regulating hemolytic transfusion reactions and will discuss potential strategies aimed at mitigating or favorably modulating complement during incompatible red blood cell transfusions.

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