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Updated: May 17, 2026

Intratracheal Inoculation of Fischer 344 Rats with Francisella tularensis

Intratracheal Inoculation of Fischer 344 Rats with Francisella tularensis

Published on: September 30, 2017

Typhoidal tularemia: 2 familial cases.

J F Faucher¹, C Chirouze, C Coutris

¹Service des Maladies Infectieuses et Tropicales, Hôpital Saint-Jacques, 25030 Besançon Cedex, France.

Case Reports in Infectious Diseases

|November 3, 2012

Summary

Tularemia, a rare infectious disease, has emerged in Eastern France. This report details two typhoidal tularemia cases in a family, highlighting the need to consider this zoonotic illness in familial fever outbreaks.

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Area of Science:

Infectious Diseases
Epidemiology
Microbiology

Background:

Eastern France was not previously recognized as an endemic region for tularemia.
Tularemia is a zoonotic disease caused by the bacterium Francisella tularensis.
Typhoidal tularemia presents with prolonged fever and can be difficult to diagnose.

Purpose of the Study:

To report two cases of typhoidal tularemia in Eastern France.
To raise awareness of tularemia in a region where it was not previously endemic.
To emphasize the importance of considering tularemia in familial fever epidemics.

Main Methods:

Case report of two patients diagnosed with typhoidal tularemia.
Serodiagnosis was used to confirm the diagnosis after fever clearance.
Epidemiological investigation to identify the source of infection.

Main Results:

Two cases of typhoidal tularemia were diagnosed in a married couple in Eastern France.
The diagnosis was confirmed via serodiagnosis.
The specific source of infection remained unclear.

Conclusions:

Tularemia should be considered in the differential diagnosis of unexplained fever in Eastern France.
Familial cases suggest a potential common zoonotic source of infection.
Increased vigilance for tularemia is warranted in this emerging endemic area.