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Updated: May 17, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

Basaloid squamous cell carcinoma - larynx.

S K Singhal¹, N K Panda, S B Mann

¹Department of Otolaryngology Head & Neck Surgery and Histopathology, Post Graduate Institute of Medical Education and Research, 160012 Chandigarh, India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India

|November 3, 2012

Summary

Basaloid squamous cell carcinoma is a rare laryngeal tumor with aggressive behavior. This study highlights two cases, emphasizing submucosal spread and preoperative radiotherapy

Keywords:

Basaloid squamous Laryngeal neoplasm carcinoma

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Last Updated: May 17, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

Area of Science:

Otolaryngology
Oncology
Pathology

Background:

Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma.
The larynx is an uncommon site for BSCC, often exhibiting aggressive behavior.
BSCC is associated with high rates of metastasis and secondary primary tumors.

Purpose of the Study:

To report two cases of laryngeal basaloid squamous cell carcinoma.
To review relevant literature on this rare laryngeal tumor.
To highlight the significance of submucosal spread and the role of preoperative radiotherapy.

Main Methods:

Case report and literature review.
Analysis of clinical presentation, histopathology, and treatment outcomes.
Emphasis on radiological and pathological findings related to tumor spread.

Main Results:

Two cases of laryngeal BSCC were identified and analyzed.
Submucosal spread was a notable characteristic in the reported cases.
The potential impact of preoperative radiotherapy on treatment was considered.

Conclusions:

Laryngeal basaloid squamous cell carcinoma is a rare entity requiring careful management.
Understanding submucosal spread is crucial for accurate staging and treatment planning.
Preoperative radiotherapy may play a role in managing this aggressive tumor.