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Updated: May 17, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Sino-nasal carcinoma with multiple cutaneous secondaries.

K Sharma¹, K K Duggal

¹Department of E.N.T., Govt. Medical College, Amritsar, Panjab.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India

|November 3, 2012

Summary

This report details a rare case of anaplastic carcinoma of the sino-nasal tract presenting with widespread skin metastases but no lymph node or distant organ involvement. This unusual presentation challenges typical metastatic patterns for this cancer type.

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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Area of Science:

Oncology
Pathology
Head and Neck Surgery

Background:

Anaplastic carcinoma of the sino-nasal tract is a rare and aggressive malignancy.
Metastatic patterns typically involve regional lymph nodes and distant organs.

Purpose of the Study:

To report an unusual case of sino-nasal anaplastic carcinoma with extensive cutaneous metastases.
To highlight a rare presentation that deviates from the expected metastatic pathway.

Main Methods:

Case report presentation.
Review of clinical presentation, imaging, and histopathological findings.
Discussion of the atypical metastatic spread.

Main Results:

The patient presented with multiple secondary skin deposits.

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Last Updated: May 17, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

No involvement of lymph nodes or other distant metastatic sites was detected.

Histopathology confirmed anaplastic carcinoma of the sino-nasal origin.

Conclusions:

This case demonstrates an atypical metastatic pattern for sino-nasal anaplastic carcinoma.
Cutaneous metastases should be considered in the differential diagnosis of unexplained skin lesions in patients with sino-nasal malignancies.
Further research into the mechanisms of unusual metastatic spread is warranted.