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Published on: September 22, 2023
Study of histopathological changes in atrophic rhinitis.
I Singh1, R M Raizada, V N Chautervedi
1Departments of Otolaryngology and Pathology, Mahatma Gandhi Institute of Medical Science, Sevagram Maharastra, India.
Summary
Histopathological examination of atrophic rhinitis biopsies revealed significant squamous metaplasia in 85% of cases. Findings also noted changes in tunica propria, mucosal glands, and vascularity, with one unique case of total squamous metaplasia.
Area of Science:
- Otolaryngology
- Pathology
Background:
- Atrophic rhinitis is a chronic nasal condition characterized by tissue degeneration.
- Understanding the histopathological changes is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the histopathological alterations in the inferior turbinate of patients with atrophic rhinitis.
- To compare findings with existing literature and identify novel changes.
Main Methods:
- Punch biopsies were obtained from the inferior turbinate of 71 consecutive atrophic rhinitis patients.
- Histopathological examination was performed to assess tissue changes.
Main Results:
- Squamous metaplasia was observed in 85% of cases.
- Tunica propria exhibited granulation tissue (41%) and chronic inflammatory infiltrate (32%).
- Mucosal glands were reduced (42%) or absent (28%); vascularity was decreased in 59% of cases.
- A unique case of total squamous metaplasia with keratinization and hypertrophy was documented.
Conclusions:
- The histopathological findings in atrophic rhinitis are largely consistent with previous reports.
- The study identified a rare instance of total squamous metaplasia, highlighting potential variations in the disease presentation.
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