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Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Olfactory neuroblastoma - our experience.

S Sharma1, J S Sahota, P Hazarika

  • 1Kasturba Medical College Hospital, 576 119 Manipal, India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|November 3, 2012
PubMed
Summary
This summary is machine-generated.

This study on olfactory neuroblastoma found that combined craniofacial resection and radiation therapy achieve excellent local control. Early detection and comprehensive follow-up using nasal endoscopes are recommended for resectable lesions.

Keywords:
EsthcsioneuroblastomaOlfactory Neuroblastoma

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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
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Area of Science:

  • Oncology
  • Neurosurgery
  • Otolaryngology

Background:

  • Olfactory neuroblastoma is a rare malignant tumor.
  • Intracranial extension presents complex surgical challenges.

Purpose of the Study:

  • To analyze outcomes of treating olfactory neuroblastoma.
  • To evaluate the efficacy of combined craniofacial resection and radiation therapy.

Main Methods:

  • Retrospective analysis of six olfactory neuroblastoma cases.
  • Surgical management by otolaryngologists and neurosurgeons.
  • Combined modality treatment including craniofacial resection and radiation therapy.

Main Results:

  • Excellent local control achieved with combined craniofacial resection and radiation therapy.
  • Data analyzed for age, sex, symptoms, stage, and treatment outcomes.

Conclusions:

  • Combined radical treatment is recommended for resectable olfactory neuroblastoma.
  • Routine use of nasal endoscopes for comprehensive follow-up is advised.