Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of essential oils in preventing hepatotoxicity: A comprehensive review.

Hepatology forum·2025
Same author

Multiomics reveal biomolecular shifts and ER stress in sleep-restricted women affecting NSC functions.

iScience·2025
Same author

Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell development.

Nature communications·2025
Same author

DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells.

Nature communications·2024
Same author

Employing Mesoporous Nitrogen Containing Carbon for Simultaneous Electrochemical Detection of Heavy Metal Ions.

Chemistry, an Asian journal·2024
Same author

Effect of anisotropy and length dispersity on electrical and optical properties of nanowire network based transparent electrodes: a computational study.

Nanotechnology·2024
Same journal

Correction: Tracheostomy Management in Oral and Oropharyngeal Carcinoma Patients: A Retrospective Study from a Multidisciplinary Protocol Approach.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2026
Same journal

Correction: Screening of Oropharyngeal Dysphagia, Laryngopharyngeal Reflux and Job Burnout in Adult Patients with Obstructive Sleep Apnea Syndrome.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2026
Same journal

Correction: Comparison of the Use of Autologous Platelet Rich Plasma with Conventional Method in Myringoplasty.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2026
Same journal

Correction to: Digital Eye Strain and Dry Nose: an Observational Study on Screen OverUse and Emerging Otorhinolaryngological Symptoms in Young Adults.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2026
Same journal

Correction: Retrospective Observational Study To Analyse Indications of Cochleostomy and Changing Trends in Use of Cochleostomy for Cochlear Implant Electrode Insertion.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2026
Same journal

Correction: Sinonasal Clear Cell Carcinoma Masquerading as Recurrent Inverted Papilloma.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2026
See all related articles

Related Experiment Video

Updated: May 17, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
05:41

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

Hearing profile in hypothyroidism.

Vikas Malik1, G K Shukla, Naresh Bhatia

  • 1Department of Otorhinolaryngology, KGMC, Lucknow, India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|November 3, 2012
PubMed
Summary
This summary is machine-generated.

Hypothyroidism can cause various types of hearing loss, affecting the ear at multiple sites. Treatment with levothyroxine showed significant hearing improvements, particularly for conductive hearing impairment.

More Related Videos

Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages
06:04

Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages

Published on: March 24, 2023

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

Related Experiment Videos

Last Updated: May 17, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
05:41

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages
06:04

Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages

Published on: March 24, 2023

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

Area of Science:

  • Otolaryngology
  • Endocrinology
  • Audiology

Background:

  • Hypothyroidism is a common endocrine disorder with potential systemic effects.
  • Auditory and vestibular functions may be impacted by thyroid hormone levels.
  • Hearing impairment is a recognized but not fully understood complication of hypothyroidism.

Purpose of the Study:

  • To investigate the audiological and vestibular effects of hypothyroidism.
  • To evaluate the impact of levothyroxine treatment on hearing function in hypothyroid patients.
  • To determine the relationship between hypothyroidism and different types of hearing loss.

Main Methods:

  • Clinical examination and laboratory investigations of audiological and vestibular systems in 45 hypothyroid patients.
  • Impedance audiometry to assess middle ear function (compliance and pressure).
  • Brainstem Evoked Response Audiometry (BERA) to evaluate auditory pathway integrity.

Main Results:

  • Hypothyroidism was associated with conductive, sensorineural, and mixed hearing impairments.
  • Levothyroxine treatment led to statistically significant improvements in hearing thresholds in 30% of ears, especially conductive loss.
  • Significant improvements were observed in middle ear compliance (50%) and pressure (87.50%) post-treatment.
  • Acoustic reflex thresholds and BERA latencies showed statistically significant changes, though BERA interpeak latencies were not significant.

Conclusions:

  • Hypothyroidism has a significant impact on auditory function, affecting the ear at multiple sites.
  • Levothyroxine therapy can lead to measurable improvements in hearing and middle ear function in hypothyroid patients.
  • A causal relationship is suggested between hypothyroidism and hearing loss, warranting further investigation.