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Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
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Published on: April 20, 2018

Neoplastic diseases of the head & neck in children

M Ashraf1, P Kumar, M Ashraf Reza

  • 1Dept. of ENT, J.N. Medical College, AMU, Aligarh.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|November 3, 2012
PubMed

Insights

Pediatric neoplasms, particularly cervicofacial malignancies, pose significant challenges in children. This study found nasopharyngeal angiofibroma and lymphoma to be the most common benign and malignant neoplasms, respectively, in children under 12.

Area of Science:

  • Pediatric Oncology
  • Head and Neck Surgery
  • Otolaryngology

Background:

  • Pediatric neoplasms are a leading cause of death in children, second only to trauma.
  • Cervicofacial malignancies in children present unique challenges due to the impact on developing head and neck structures.
  • Treatment and disease progression can lead to adverse effects on critical anatomical areas.

Purpose of the Study:

  • To analyze the incidence and types of pediatric neoplasms in the cervicofacial region.
  • To identify the most common benign and malignant neoplasms in this age group.
  • To highlight the need for a multidisciplinary approach in managing these conditions.

Main Methods:

  • A retrospective study of 106 children under 12 years of age.
  • Data collected from 1999 to 2003 at JNMC, Aligarh.
  • Analysis of tumor types, sites of involvement, and patient demographics.

Main Results:

  • Out of 106 cases, 70 were benign and 36 were malignant neoplasms.
  • The nasopharynx was the most frequent site of neoplasm occurrence.
  • Nasopharyngeal angiofibroma was the most common benign tumor, while lymphoma was the most common malignant neoplasm.

Conclusions:

  • Pediatric cervicofacial neoplasms require specialized management strategies.
  • Early diagnosis and intervention are crucial for better outcomes.
  • A collaborative, team-based approach is essential for effective disease mitigation.

Keywords:
LymphomaNasopharyngeal angiofibromaNeoplasmRhabdomyosarcoma

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