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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Peripheral primitive neuroectodermal tumor of head-neck region: our experience
Anirban Ghosh1, Somnath Saha, Sudipta Pal
1Department of ENT, Anandolok Hospital, Raniganj, India.
Summary
Peripheral primitive neuroectodermal tumors (PNETs) are rare, aggressive malignancies. This case series highlights their poor prognosis and early spread in the head and neck region.
Area of Science:
- Oncology
- Pathology
- Head and Neck Surgery
Background:
- Peripheral primitive neuroectodermal tumors (PNETs) are rare malignant round cell tumors.
- PNETs in the head and neck region are exceptionally uncommon, presenting diagnostic and therapeutic challenges.
Purpose of the Study:
- To report four rare cases of PNETs in the sinonasal region and neck.
- To discuss treatment strategies, biological behavior, and prognostic outcomes of these rare tumors.
Main Methods:
- Case series presentation of four patients diagnosed with PNETs.
- Review of treatment options, clinical behavior, and patient follow-up.
- Immunohistochemistry utilized for tumor differentiation.
Main Results:
- The study included four patients (three female, one male) aged 8-40 years.
- Two patients experienced disease-related mortality within 4-6 months post-treatment.
- The remaining two patients are under follow-up, indicating aggressive tumor behavior.
Conclusions:
- PNETs in the head and neck are aggressive with a poor prognosis and high mortality.
- Early local and systemic spread is characteristic, even after chemoradiation.
- Immunohistochemistry is crucial for accurate diagnosis of this rare entity.
