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[Acute childhood pancreatitis caused by valproate]

Jasminka Jakobović1, Diana Butković, Ljiljana Popović

  • 1Zavod za anesteziologiju, reanimatologiju i intenzivno lijecenje, Klinika za djecje bolesti Zagreb, Klaićeva 16, Zagreb. jjakobov@inet.hr

Lijecnicki Vjesnik
|November 6, 2012
PubMed

Insights

Pediatric pancreatitis shares symptoms with adults but often stems from drug side effects. Natrium valproate, an antiepileptic, can rarely cause this condition in children.

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Pharmacology

Background:

  • Pediatric pancreatitis presents similarly to adult cases, including abdominal pain and elevated amylase.
  • While drug-induced pancreatitis is more common in children than adults, specific causative agents require identification.

Observation:

  • A case of pancreatitis in a young girl with Rett's syndrome is presented.
  • The patient was undergoing treatment with natrium valproate, a known, albeit rare, potential teratogen.

Findings:

  • Natrium valproate, an antiepileptic medication, was identified as the likely cause of pancreatitis.
  • Abdominal ultrasound findings were non-specific, necessitating further investigation.

Implications:

  • This case highlights the importance of considering medication side effects in pediatric pancreatitis diagnosis.
  • Abdominal computed tomography (CT) is crucial for confirming suspected pancreatitis in children on valproate therapy when initial tests are inconclusive.

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