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Updated: May 17, 2026

Whole-mount Retinal Organoid Visualization with Cellular Resolution
Published on: June 20, 2025
[Maturation and plasticity of visual system: neurogenesis, synaptogenesis, and myelogenesis. Report I. Retina and
Abstract:
In this review up-to-date conception of retinal neurogenesis and synaptogenesis is presented, specific stages information of cellular and synaptic structure of retinal synaptic pathways and their propable mechanisms are briefly discussed. Neurogenesis is largely determined geneticaly, and molecular cues are assumed to play a crucial role in retinal synaptogenesis. The initially established retinal synaptic circuitry is profoundly refined during postnatal development to form specific synaptic pathways. In early developing retina, retinal ganglion cells fire periodic bursts of action potentials that are highly correlated and propagate across the retina in a wave-like fashion. The model of retinal-wave-dependent synaptic plasticity seems to be suited for the Hebbian learning rule.
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