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Updated: May 17, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
Involvement of glucocorticoid receptor on hyperpyrexia induced by methamphetamine administration
S Yoshida1, H Kinoshita, T Tatara
1Department of Anesthesia, Hyogo College of Medicine, Nishinomiya, Japan.
Unlabelled:
We have investigated the involvement of glucocorticoid on methamphetamine (MA) induced hyperpyrexia using a bio-telemetric system. A significant level of hyperpyrexia was observed in MA administered rats. In contrast, increase of body temperature was suppressed by adrenalectomy or by the administration of RU-486, an antagonist of the glucocorticoid receptor. These data suggest that the glucocorticoid receptor may be involved in hyperpyrexia induced by MA.
Keywords:
methamphetamine - hyperpyrexia - glucocorticoid - corticosterone.
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