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Genetic-epidemiologic study of haemophilia A and B in Hungary
L István1, A Czeizel, M Kerényi
1Department of Blood Transfusion, Markusovszky Hospital of County Vas, Szombathely.
Human Heredity
|January 1, 1990
Abstract:
All known surviving haemophiliacs A and B and their relatives were reexamined by laboratory and clinical methods and evaluated by a genetic-epidemiologic approach in 4 north-western countries of Hungary. The prevalence of haemophilia A and B patients born in the fifties was 2.73 and 0.25 per 10,000 persons, respectively. The reproductive fitness was found to be 0.3 in haemophilia A, and 0.8 in haemophilia B patients. The mutation rates calculated by the indirect method were 6.3 x 10(-5) for haemophilia A and 0.2 x 10(-5) for haemophilia B.