Related Experiment Video
Updated: May 17, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Immediate allergic cross-reactivity to levobupivacaine and ropivacaine
A L Calderon1, N Diot, F Benatir
1Department of Anaesthesiology and Intensive Care, Édouard Herriot Hospital, HCL, Lyon, France.
Abstract:
Allergic reactions to amide local anaesthetic agents are rare. We report the case of a 74-year-old man who suffered anaphylaxis, presenting with cardiovascular collapse, immediately after receiving regional anaesthesia on two separate occasions, the first involving the use of levobupivacaine and the second using ropivacaine. Skin testing revealed positive reactions to both levobupivacaine and ropivacaine, and negative reactions to articaine and lidocaine. Severe allergic reactions can be caused by the amide local anaesthetic drugs, levobupivacaine and ropivacaine.
More Related Videos
Related Concept Videos
Allergic Reactions: Anaphylaxis
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Cross-reactivity
Allergic Reactions
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
