Related Experiment Videos
Myocardial infarction following sublingual administration of isosorbide dinitrate
S Scardi1, B Zingone, C Pandullo
1Department of Cardiology, Ospedale Maggiore, Trieste, Italy.
International Journal of Cardiology
|March 1, 1990
Abstract:
A 78-year-old with healed septal necrosis suffered a recurrent myocardial infarction of the anterior wall following the administration of isosorbide dinitrate 5 mg sublingually. After detailing the course of events, we discuss the role of paradoxical coronary spasm and hypotension-mediated myocardial ischemia occurring downstream to significant coronary arterial stenosis in the pathophysiology of acute coronary insufficiency.