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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...

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Related Experiment Video

Updated: May 17, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

Cell-based genomic screening: elucidating virus-host interactions.

Debasis Panda1, Sara Cherry

  • 1Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, United States.

Current Opinion in Virology
|November 6, 2012
PubMed
Summary
This summary is machine-generated.

Understanding virus-host interactions is key to fighting infections. Cell-based screening and RNAi technology reveal cellular factors impacting viral replication and immunity, aiding therapeutic target discovery.

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Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

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11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

Related Experiment Videos

Last Updated: May 17, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy
08:51

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

Area of Science:

  • Virology
  • Cell Biology
  • Immunology

Background:

  • Viruses utilize host cell machinery for replication while evading immune responses.
  • Studying virus-host interactions offers insights into cellular processes and viral pathogenesis.
  • Characterizing these interactions is crucial for understanding disease and developing interventions.

Purpose of the Study:

  • To review recent advancements in understanding the virus-host interface.
  • To discuss the role of cell-based screening and RNAi in this research area.
  • To explore challenges and future directions in the field of viral infection research.

Main Methods:

  • Utilizing cell-based screening assays.
  • Employing RNA interference (RNAi) technology.
  • Analyzing findings from recent studies on virus-host interactions.

Main Results:

  • Identification of cellular factors influencing viral infection.
  • Expanded understanding of viral replication mechanisms.
  • Discovery of potential therapeutic targets for antiviral strategies.

Conclusions:

  • Cell-based screening and RNAi have significantly advanced the study of virus-host interactions.
  • Continued research holds promise for novel therapeutic strategies against viral diseases.
  • The field faces challenges but offers exciting future prospects for controlling viral infections.