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Reemergence of new variant G3 rotavirus in Japanese pediatric patients, 2009-2011

Aksara Thongprachum1, Wisoot Chan-it, Pattara Khamrin

  • 1Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
|November 6, 2012
PubMed

Insights

Rotavirus G3P[8] became the dominant strain in Japanese children with acute gastroenteritis, replacing G1 strains. This emerging G3 rotavirus poses a potential global health concern.

Area of Science:

  • Virology
  • Molecular Epidemiology
  • Public Health

Background:

  • Rotavirus is a leading cause of severe gastroenteritis in young children worldwide.
  • Understanding rotavirus epidemiology and genotype prevalence is crucial for disease control and vaccine development.

Observation:

  • A study investigated rotavirus in 5 Japanese prefectures from 2009-2011, analyzing 831 fecal samples.
  • Rotavirus was detected in 19.9% of samples, with higher rates in 2010-2011 and peak prevalence in children aged 12-23 months.
  • Rotavirus detection occurred throughout an 8-month period, peaking in April.

Findings:

  • The G3P[8] genotype was the most prevalent (54.5%), followed by G1P[8] (29.1%).
  • Rotavirus G3 strains emerged as predominant, supplanting previously dominant G1 strains.
  • Phylogenetic analysis linked these G3 strains to a "new variant G3" strain identified in Japan in 2003-2004.

Implications:

  • The rise of rotavirus G3 indicates it's a major cause of infection across Japan.
  • The emergence and potential global spread of this rotavirus G3 strain warrant further monitoring and investigation.

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