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Cyclophilins: proteins in search of function
Sumita Kumari1, Suchismita Roy2, Prabhjeet Singh3
1Sher-e-Kashmir University of Agricultural Sciences and Technology; Jammu, India.
Plant Signaling & Behavior
|November 6, 2012
Summary
Plant cyclophilins, crucial molecular chaperones, play vital roles in cellular processes and stress responses. This review explores their functions and importance in plant survival under various environmental stresses.
Area of Science:
- Biochemistry
- Molecular Biology
- Plant Science
Background:
- Cyclophilins are a conserved subgroup of immunophilins, known for their protein folding and chaperoning activities.
- While most cyclophilins exhibit PPIase activity, some have evolved functions independent of this enzymatic role.
- Plant cyclophilins are implicated in diverse cellular functions and regulatory pathways, including responses to environmental stress.
Purpose of the Study:
- To review the known functions of plant cyclophilins.
- To explore the role of cyclophilins in plant stress responses.
- To highlight the physiological relevance and molecular basis of stress-responsive cyclophilin expression in plants.
Main Methods:
- Literature review of existing research on plant cyclophilins.
- Analysis of studies linking cyclophilins to various cellular processes.
- Examination of evidence for cyclophilin involvement in plant stress tolerance.
Main Results:
- Cyclophilins act as molecular chaperones, aiding in protein folding and cellular processes.
- Plant cyclophilins are associated with diverse functions, including scaffolding and chaperoning.
- Several cyclophilin members are directly linked to plant responses to multiple environmental stresses.
Conclusions:
- Plant cyclophilins are fundamentally important for plant survival due to their ubiquitous nature and diverse roles.
- Understanding the stress-responsive expression of plant cyclophilins is crucial for elucidating their physiological relevance.
- Further research is needed to fully understand the molecular mechanisms underlying cyclophilin functions in plant stress adaptation.
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