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Related Concept Videos

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...

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Related Experiment Video

Updated: May 17, 2026

Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration
09:33

Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration

Published on: October 3, 2019

Expression and function of cell adhesion molecules during neural crest migration.

Sonja J McKeown1, Adam S Wallace, Richard B Anderson

  • 1Department of Anatomy and Neuroscience, University of Melbourne, 3010 VIC, Australia. s.mckeown@unimelb.edu.au

Developmental Biology
|November 6, 2012
PubMed
Summary

Cell adhesion molecules guide neural crest cell migration, crucial for development. This review examines cadherins, integrins, and immunoglobulin superfamily members involved in neural crest cell movement across species and axial levels.

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Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration
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Published on: October 3, 2019

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Neuroscience

Background:

  • Neural crest cells are a transient population of highly migratory cells originating from the dorsal neural tube.
  • These cells differentiate into a diverse range of cell types, including neurons, glia, craniofacial cartilage, bone, and melanocytes.
  • Neural crest cell migration is a complex process guided by intricate molecular interactions within the microenvironment.

Purpose of the Study:

  • To review the expression and function of key cell adhesion molecules (CAMs) during neural crest cell migration.
  • To explore the roles of cadherins, integrins, and immunoglobulin superfamily CAMs in this process.
  • To compare the roles of CAMs and associated proteases across different axial levels and vertebrate species.

Main Methods:

  • Literature review focusing on studies of neural crest cell migration.
  • Analysis of expression patterns and functional data for specific CAMs and proteases.
  • Comparative analysis across different species and embryonic regions.

Main Results:

  • Cadherins, integrins, and immunoglobulin superfamily CAMs are differentially expressed and play critical roles in regulating neural crest cell adhesion, migration, and differentiation.
  • Proteolytic enzymes that cleave CAMs are also integral to modulating cell-cell and cell-matrix interactions.
  • Variations in CAM expression and function exist depending on the axial origin of the neural crest and the species.

Conclusions:

  • Cell adhesion molecules and their regulators are essential for orchestrating the complex migratory behavior of neural crest cells.
  • Understanding these molecular mechanisms provides insights into vertebrate development and potential therapeutic targets for developmental disorders.