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Updated: May 17, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
Published on: May 14, 2021
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling
Peter Vandenabeele1, Mathieu J M Bertrand
1Department for Molecular Biomedical Research, VIB, B-9052 Ghent, Belgium. peter.vandenabeele@dmbr.vib-ugent.be
Abstract:
An inflammatory response is initiated when innate immune pattern-recognition receptors (PRRs) expressed by different cell types detect constituents of invading microorganisms and endogenous intracellular molecules released by dying cells. The intracellular cascades activated by PRRs induce the expression and maturation of inflammatory molecules that coordinate the removal of the infectious agents and of the infected or damaged cells. In this Review, we discuss the findings implicating members of the inhibitor of apoptosis protein (IAP) family in the ubiquitylation-dependent regulation of PRR signalling. Understanding the role of IAPs in innate immunity may open new therapeutic perspectives for the treatment of PRR-dependent inflammatory diseases.
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