Echogenic splenic lesions in a child with type B Niemann-Pick disease

We report the case of a 15-year-old boy with Niemann-Pick disease type B with characteristic sonographic findings of splenic involvement. There were multiple well-defined echogenic nodular lesions within the spleen parenchyma, and these lesions were surrounded by ring-like blood flow on color Doppler imaging. Most of the patients with Niemann-Pick disease type B are children and they undergo repeated imaging studies. Therefore, familiarity with sonographic findings of the disease is required.