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Multivalent proteoglycan modulation of FGF mitogenic responses in perivascular cells

Sabrina Cattaruzza1, Ugur Ozerdem, Martin Denzel

  • 1S.O.C. for Experimental Oncology 2, The National Cancer Institute Aviano, CRO-IRCCS, Via Pedemontana Occidentale 12, 33081, Aviano, PN, Italy. sabrina.cattaruzza@libero.it

Angiogenesis
|November 6, 2012
PubMed
Summary

Perivascular NG2 proteoglycan is crucial for FGF-2-induced angiogenesis by retaining FGF-2 for receptor presentation. NG2 acts as a co-receptor for FGFRs, enhancing FGF signaling and pericyte response.

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