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Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

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Related Experiment Video

Updated: May 17, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

Left ventricular function in pulmonary hypertension.

Hirohisa Amano1, Shigeru Toyoda, Takuo Arikawa

  • 1Department of Cardiovascular Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu, 321-0293, Tochigi, Japan.

Heart and Vessels
|November 6, 2012
PubMed
Summary
This summary is machine-generated.

Pulmonary hypertension treatment improved left ventricular function. Reducing right ventricular pressure enhanced left ventricular stroke volume and diastolic function, suggesting improved interventricular septal performance.

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Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
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Last Updated: May 17, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
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Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

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Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
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Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
10:33

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

Area of Science:

  • Cardiology
  • Pulmonology
  • Echocardiography

Background:

  • Pulmonary hypertension (PH) significantly impacts cardiac function, particularly the left ventricle (LV).
  • Understanding the relationship between right ventricular (RV) pressure and LV performance is crucial for PH management.

Purpose of the Study:

  • To investigate the effects of pulmonary artery vasodilators on LV function in patients with PH.
  • To explore the correlation between changes in RV systolic pressure (RVSP) and LV parameters post-treatment.

Main Methods:

  • Echocardiography was used to assess LV and RV function in 11 PH patients.
  • Measurements were taken before and 6 months after treatment with pulmonary artery vasodilators (beraprost or sildenafil).

Main Results:

  • A significant correlation was found between RVSP reduction and improved LV outflow tract velocity-time integral (r = -0.730) and mitral valve velocity-time integral (r = -0.621).
  • RVSP reduction also correlated with improved early diastolic myocardial velocity at the medial mitral annulus (r = -0.675).
  • No significant correlation was observed between RVSP changes and LV ejection fraction, LV diastolic dimension, or systolic blood pressure.

Conclusions:

  • Pulmonary artery vasodilator treatment in PH patients can improve LV function.
  • Reduced RVSP may enhance LV preload, increasing stroke volume and improving diastolic function, potentially via improved interventricular septal mechanics.