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Related Experiment Video

Updated: May 17, 2026

A Minimally Invasive Model of Aortic Stenosis in Swine

A Minimally Invasive Model of Aortic Stenosis in Swine

Published on: October 20, 2023

Circumferential ascending aortic strain and aortic stenosis.

Rogério Teixeira¹, Nádia Moreira, Rui Baptista

¹Serviço de Cardiologia, Centro Hospitalar e Universitario de Coimbra, Av. Bissaya Barreto Praceta Prof. Mota Pinto, Coimbra, Portugal. rogeriopteixeira@gmail.com

European Heart Journal. Cardiovascular Imaging

|November 6, 2012

Summary

Two-dimensional speckle tracking echocardiography can measure circumferential ascending thoracic aortic strain (CAAS) in patients with aortic stenosis. Stroke volume index and left ventricular afterload significantly influence CAAS measurements in these patients.

Keywords:

2D-ST strain imaging Aortic stenosis Circumferential ascending aortic strain Low flow

Related Experiment Videos

Last Updated: May 17, 2026

A Minimally Invasive Model of Aortic Stenosis in Swine

A Minimally Invasive Model of Aortic Stenosis in Swine

Published on: October 20, 2023

Area of Science:

Cardiology
Medical Imaging
Echocardiography

Background:

Aortic stenosis (AS) assessment lacks standardized methods for thoracic aortic deformation.
Two-dimensional speckle tracking (2D-ST) echocardiography's role in measuring circumferential ascending thoracic aortic strain (CAAS) in AS is not well-defined.

Purpose of the Study:

To evaluate thoracic ascending aortic deformation using 2D-ST echocardiography in patients with aortic stenosis.
To assess the relationship between aortic deformation and hemodynamic parameters in AS.

Main Methods:

Included 45 patients with aortic valvular area (AVA) ≤0.85 cm²/m².
Measured global peak CAAS and calculated corrected CAAS (CAAS/pulse pressure).
Assessed aortic stiffness (β2 index) and stratified patients by stroke volume index (SVI) into low-flow (Group A) and normal-flow (Group B) groups.

Main Results:

Mean CAAS was 6.3 ± 3.0%, predicted by SVI and valvulo-arterial impedance (Zva).
Corrected CAAS correlated with aortic stiffness index (β1) and was predicted by SVI, Zva, and systemic arterial compliance.
The β2 index was significantly higher in low-flow patients and predicted by SVI and pulse pressure (PP).

Conclusions:

Stroke volume index (SVI) and left ventricular afterload-related variables are key determinants of 2D-ST global CAAS in moderate-to-severe AS.
Global CAAS demonstrated higher accuracy in predicting low flow compared to Zva, systolic function, and systemic vascular resistance.